Clinical experience with fetal hemoglobin induction therapy in patients with b-thalassemia

نویسندگان

  • Khaled M. Musallam
  • Ali T. Taher
  • Maria Domenica Cappellini
  • Vijay G. Sankaran
چکیده

Clinical experience with fetal hemoglobin induction therapy in patients with b-thalassemia Khaled M. Musallam, Ali T. Taher, Maria Domenica Cappellini, and Vijay G. Sankaran Department of Medicine and Medical Specialties, Fondazione IRCCS Ca’ Granda, Ospedale Maggiore Policlinico, University of Milan, Milan, Italy; Department of Internal Medicine, American University of Beirut Medical Center, Beirut, Lebanon; Division of Hematology/Oncology, Boston Children’s Hospital, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA; and Broad Institute and Whitehead Institute for Biomedical Research, Cambridge, MA

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 Background: A Thalassemia intermedium is an autosomal recessive disease that from clinical and also genotypic view contains a very heterogeneous group of hemoglobinopathies and severity of disease is placed between thalassemia major and minor. High levels of fetal hemoglobin have a major impact on the severity of this disease, so that increased production of HbF, reduces these veritie...

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تاریخ انتشار 2013